Supplemental Facts

Active Ingredients Found in GenEpic

Espinheira Santa (Maytansine)- Espinheira Santa (Maytenus ilicifolia) has a much longer and well documented history of use in urban areas and in South American herbal medicine practices than in tribal areas, probably because of the types of illnesses that it treats. It is also one of the few tropical South American medicinal plants that have been the subject of so many clinical studies, fueled by its effectiveness in treating ulcers and even cancer with research beginning as early as the mid-1960′s.(2, 3) research revealed that Espinheira Santa as well as a few other species in the Maytenus family contain anti-biotic compounds which showed potent anti-tumor and anti-leukemic activities at very low dosages.(4 – 8) Two of these compounds, maytansine and mayteine, were tested in cancer patients in the United States and South America in the 1970′s.(9 – 13) Although there were some significant regressions in ovarian carcinoma and some lymphomas with Maytansine, (11) further research was not continued due to the toxicity at the high dosages used.(14) Research with the compound Mayteine, revealed little to no toxicity (6, 9, 10) and validated its uses in traditional and folk medicine for various types of skin cancers (3, 15) and cancer research is still ongoing in South America with this compound. In traditional medicine today, an application of the leaves of Espinheira Santa is employed as an ointment for treating skin cancer and a decoction as a wash for cancers.(16)

Graviola (Acetogenins) – In a 1976 plant screening program by the National Cancer Institute, graviola leaves and stem showed active cytotoxicity against cancer cells and researchers have been following up on these findings since. Much of the cancer research on graviola focuses on a novel set of phyto-chemicals called Annonaceous acetogenins. Graviola produces these natural compounds in its leaf and stem, bark, and fruit seeds. Three separate research groups have isolated these acetogenin compounds in graviola which have demonstrated significant antitumorous and anticancerous properties, and selective toxicity against various types of cancer cells (without harming healthy cells) publishing eight clinical studies on their findings. Many of the acetogenins have demonstrated selective toxicity to tumor cells at very low dosages– as little as 1 part per million. Four studies were published in 1998 which further specify phytochemicals and acetogenins which are demonstrating the strongest anticancerous, antitumorous, and antiviral properties.

Thus far, specific acetogenins in graviola have been reported to be selectively toxic to these types of tumor cells: lung carcinoma cell lines; human breast solid tumor lines; prostate adenocarcinoma; pancreatic carcinoma cell lines; colon adenocarcinoma cell lines; liver cancer cell lines; human lymphoma cell lines; and multi-drug resistant human breast adenocarcinoma. Mode of action studies in three separate laboratories have recently determined that these acetogenins are superb inhibitors of enzyme processes that are only found in the membranes of cancerous tumor cells. Purdue University, in West Lafayette, Indiana, has conducted a great deal of the research on the acetogenins, much of which has been funded by The National Cancer Institute and the National Institute of Health (NIH). Thus far Purdue University and it’s staff have filed at least nine U.S. and international patents on their work around the antitumorous and insecticidal properties and uses of these acetogenins.

An interesting in vivo study was published in March of 2002 by researchers in Japan, who were studying various acetogenins found in several species of plants. They inoculated mice with Lewis lung carcinoma cancer cells. One third received nothing, one third received the chemotherapy drug adriamycin, and one third received the main graviola acetogenin, annonacin (at a dosage of 10 mg/kg). At the end of two weeks, five of the six in the untreated control group were still alive and lung tumor sizes were then measured. The adriamycin group showed a 54.6% reduction of tumor mass over the control group–but 50% of the animals had died from toxicity (three of six). The mice receiving annonacin were all still alive, and the tumors were inhibited by 57.9%–slightly better than adriamycin–and without toxicity.

Anon. Unpublished data, National Cancer Institute. Nat Cancer Inst Central Files (1976). From NAPRALERT Files, University of Illinois, 1995.

Wu, F. E., et al. “Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the leaves of Annona muricata.” J. Nat. Prod. 1995; 58(6): 830-36

Jaramillo, M. C., et al. “Cytotoxicity and antileishmanial activity of Annona muricata pericarp.” Fitoterapia 2000; 71(2): 183-6.

Betancur-Galvis, L., et al. “Antitumor and antiviral activity of Colombian medicinal lant extracts.” Mem. Inst. Oswaldo Cruz 1999; 94(4): 531-35.

Cats Claw-A 2001 in vitro study that cat’s claw directly inhibited the growth of a human breast cancer cell line by 90%, while another research group reported that it inhibited the binding of estrogens in human breast cancer cells in vitro. Swedish researchers documented it inhibited the growth of lymphoma and leukemia cells in vitro in 1998. Early reports on Keplinger’s observatory trials with cancer patients taking cat’s claw in conjunction with such traditional cancer therapies as chemotherapy and radiation reported fewer side effects to the traditional therapies (such as hair loss, weight loss, nausea, secondary infections, and skin problems). Subsequent researchers have shown how these effects might be possible: they have reported that cat’s claw can aid in DNA cellular repair and prevent cells from mutating; it also can help prevent the loss of white blood cells and immune damage caused by many chemotherapy drugs (a common side effect called leukopenia).

Sheng Y, Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa. Anticancer Res. 1998 Sep-Oct;18(5A):3363-8.

Sheng Y, Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine. 2000 Apr;7(2):137-43.

Maitake (Beta-glucan)-Beta-glucan also responds to tumor cells by stimulating the production of small protein substances within the phagocytic cells called cytokines. Cytokines stimulate the macrophages to inhibit tumor cell replication (cytostatic action) and kill the tumor (cytolytic action). (10)

Because of beta-glucan’s demonstrated ability to activate macrophages and T-cells, researchers have used it as an anti-cancer treatment by itself, or as a non-toxic adjuvant to chemotherapy. In studies of animals injected with tumor cells, researchers found that animals that were also treated with beta-glucan had decreased liver metastases compared with control animals. The beta-glucan-treated mice had a 28 percent increase in survival compared to those without beta-glucan. (11)

Although most research on beta-glucan has been done with animals, there have been a number of human studies. In 1975, the Journal of the National Cancer Institute reported on the anti-cancer effects of beta-glucan on nine cancer patients, who suffered from skin, breast, or lung cancer. Beta-glucan was injected directly into the tumors. In all cases, beta-glucan reduced the size of the tumor within five days, resulting from infiltration of immune cells into the cancerous area with subsequent destruction of the cancer cells. (12)

A number of clinical studies have been conducted in Japan with lentinan (a beta-1,3-1,6-glucan derived from the shiitake mushroom). Lentinan is considered a drug in Japan, where it is approved for clinical use. Japanese scientists have shown that treatment of advanced-cancer patients with lentinan, by intravenous injection, results in increasednumber and activity of immune killer cells (13) and prolonged survival — sometimes in excess of five or more years. (14)

According to researchers at the National Cancer Center in Japan, complete tumor elimination was experienced in about 80% of cancer-induced animals fed extracts from maitake, shiitake, and reishi mushrooms. Compounds of each of these mushrooms increase the tumor-fighting activity of NK cells [natural killer cells of the immune system] and improve antibody responses, but maitake seems to have the strongest and most consistent effect. … Unlike other mushroom extracts, the maitake extract shows strong anticancer activity even when administered orally.” (Diamond)

Mutamba (procyanidin B-2)-Mutamba is called guasima or guacima in Mexico, where it has a very long history of indigenous use. A phytochemical analysis of mutamba bark shows that it is a rich source of this natural chemical compound and it has been documented with other biological activities as well. Of particular note (in 1990), a Brazilian research group demonstrated that a crude extract of mutamba was cytotoxic to cancer cells in vitro, exhibiting a 97.3% inhibition rate. It later was shown in independent research that procyanidin B-2 also demonstrated antitumorous and anticancerous effects (even against melanoma) as well as hypotensive and kidney protective properties. In a 1995 in vitro study, mutamba also demonstrated antiviral activity against Herpes simplex type 1. These studies could certainly explain why mutamba has been used so effectively in herbal medicine systems for many types of gastrointestinal problems, such venereal diseases as gonorrhea and syphilis, and upper respiratory conditions (e.g. pneumonia and bronchitis). Subsequent research focusing on particular chemicals found in mutamba documented their ability to interfere with prostaglandin synthetase, a process by which bacteria and pathogens replicate. Scientists showed that these phytochemicals interacted with a cholera toxin–preventing chloride secretion and the resultant diarrhea.

Suma (Pfaffic Acids)-The root acontains novel phytochemicals including saponins, pfaffic acids, glycosides, and nortriterpenes. The specific saponins found in the roots of suma include a group of novel phytochemicals that scientists have named pfaffosides. These saponins have clinically demonstrated the ability to inhibit cultured tumor cell melanomas (in vitro) and help to regulate blood sugar levels (in vivo). The pfaffosides and pfaffic acid derivatives in suma were patented as antitumor compounds in several Japanese patents in the mid-1980s. In a study described in one of the patents, researchers reported that an oral dosage of 100 mg/kg (of suma saponins) given to rats was active against abdominal cancer. The other patents and Japanese research report that the pfaffic acids found in suma root had a strong in vitro activity against melanoma, liver carcinoma, and lung carcinoma cells at only 4–6 mcg of pfaffic acids.

Burdock Root- The root of this plant is considered a diuretic and can also be used for stomach ailments. It neutralizes and eliminates poisons. It is a detoxifier for the blood, kidneys, and liver. Considered one of the best uric acid eliminators, it relieves congestion in the lymphatic system.

Kelp- Rich source of vitamins, especially B vitamins, minerals, and trace elements. Beneficial to the brain tissue, membranes surrounding the brain, thyroid, sensory nerves, spinal cord, nails, and blood vessels.  Helps regulate metabolism. Contains approximately 30 major minerals and trace minerals. Also high in iodine for the skin.

Garlic- Stimulates activity of the digestive organs and relieves problems associated with poor digestion. Can be used as an expectorant to reduce chronic stomach and intestinal catarrh. It regulates the action of the liver and gall bladder.  It is helpful for all intestinal infections.  It helps to lower blood pressure and reduces arteriosclerosis.  Prevents blood platelets from sticking to each other.

Dandelion Root- This plant has two particularly important uses: To promote the formation of bile and to remove excess water from the body in edemous conditions. It acts to remove poisons from the body and can also act as a tonic stimulant. Dandelion is claimed to be effective for liver problems.

Marshmallow- The root of this plant is used primarily for the intestines, kidneys, and the bladder. This combats intestinal disorders, digestive upsets, and fluid retention.  Soothes and heals skin and other tissues.  Helps to heal inflammatory conditions in bronchitis, coughs and other respiratory conditions.

Acacia Gum- The main effect is to form a protective, soothing, coating over inflammations in the respiratory, alimentary, and urinary tracts. It is helpful for coughs, sore throats, and catarrh.

Milk Thistle- Contains some of the most potent liver protecting substances known. Prevents free radical damage in the liver and kidneys. It stimulates new liver cells and is an excellent immune system builder.

Red Clover- Acts as an antibiotic, appetite suppressant, blood purifier and relaxant. Fights kidney and liver disease.

Safflower Petals- These petals are diuretic and diaphoretic. They are good for the skin, stomach, kidneys, pancreas and nerves.  Useful aid for the digestion process.  Helps to digest oils and helps to eliminate cholesterol and uric acid.

Psyllium Seed Husk- Assists peristalsis in the intestines and is good for wall and valve cleansing in the colon.  Eliminates toxins. Creates bulk and fiber.

Cat’s Claw- The bark and roots of this plant enhances the action of the white blood cells. It acts as an antioxidant and anti-inflammatory.

Astragalus- This root is an immune system protector. Aids adrenal gland function and digestion. Increases metabolism and provides energy to combat fatigue. Is good for immune deficiencies.

Shitake-  This mushroom strengthens the T-cell function. It contains 18 amino acids and is rich in all the B Vitamins. It also contains an effective polysaccharide although different than the Maitake mushroom.

Reishi- This mushroom has been used to prevent high blood pressure and heart disease, promote vitality, control cholesterol and treat fatigue.  As with other mushrooms it builds resistance to disease.

Aloe Vera 200X- This Aloe Vera can be ingested to aid in the immune system. It is a pure blend of muccopolysaccharides that not only assist in joint health, skin health, and collagen production but also boosts immunity.

Royal Jelly – This substance created by nurse bees is the sole food of the queen bee that lays approximately 2,000 eggs per day and lives 40 times longer than other bees.  It is the only natural source of acetylcholine and contains all of the B complex vitamins. It contains 18 amino acids, minerals, enzymes, hormones, and many vitamins. It is used to strengthen the immune system and treat several types of disorders.

Vitamin A (Alpha and Beta-Carotene)- Best known for its anti-infection and night vision properties.  Necessary in bone and teeth development. Helps form connective tissue for a framework of skeletal tissue. It is a precursor to vitamin A and considered to be a powerful free radical scavenger. It is the body’s first line of defense against invading microorganisms and toxins.  Beta-Carotene promotes the immune response and the bioflavanoids found in beta-carotene are highly effective in maintaining cell nutrition.

Vitamin B1 (GPM) 25%- Called the Morale Vitamin. Essential for the health of the entire nervous system. Assists the body in utilizing energy from metabolism of carbohydrates. Needed during pregnancy, lactation, and strenuous exercise. Nourishes brain, eyes, ears, hair, heart, liver, and kidneys.

Vitamin B2 (GPM) 10%- Called the Youth Vitamin. Essential for proper enzyme formation, normal growth, and metabolism of fats, carbohydrates, and protein. Balances production of red blood cells and hormones and absorption of iron. Provides stamina.

Vitamin B3 (GPM)25%- Essential in energy, metabolism, and for production of male and female hormones. Promotes good physical and mental health. It is involved in production of hydrochloric acid for the digestive system. It lowers cholesterol and improves circulation.

Vitamin B5 (GMP) 25%-  Called the Anti Stress Vitamin. Essential for health of adrenal glands and hormones. The formation of antibodies aids in vitamin utilization, and converts fats, carbohydrates, and proteins into energy. It is involved in the production of neurotransmitters. It has also been shown to be an effective healing agent.

Vitamin B6 (GMP) 20%- Called the Vitality Vitamin.  It is essential for conversion of protein foods into amino acids and production of antibodies. Provides a balance of minerals, potassium and sodium for the entire nervous system. It participates in more than 60 enzymatic reactions involved in the metabolism of amino and fatty acids. This vitamin is necessary for healthy blood and blood vessels.

Vitamin B9 (GPM) 1 % (Folic Acid)- This water-soluble vitamin is very important during pregnancy, helps prevent birth defects and corrects anemia.  It provides nutrients to strengthen hair, skin, and nails.  It acts as a coenzyme of DNA and RNA synthesis. It is essential for the absorption of iron and calcium.

Vitamin B12 (yeast concentrate 0.5%)- Effective blood builder needed to prevent anemia. It aids folic acid in regulating the formation of red blood cells and utilization of iron. Essential in food metabolism, especially carbohydrates and fats. Promotes healthy skin, blood cells, mucus membranes, and the nervous system. Among other important features, Vitamin B12 is required for proper digestion, absorption of foods, the synthesis of protein, and the metabolism of carbohydrates and fats. Strict vegetarians are reminded that they require Vitamin B12 supplementation, since it is found almost exclusively in animal tissues.

Vitamin C (GPM) 25%- This water-soluble vitamin is well known for its ability to advance wound healing. Vitamin C supplementation is said to moderate the severity of the common cold and reduce intraocular pressure in glaucoma, the inflammation of periodontal disease and intolerance to heat. Vitamin C helps concentrate vasodilating prostaglandin’s to help relieve chest tightness in asthmatics. It can help reduce serum cholesterol and triglycerides levels, which are risk factors in heart disease and atherosclerosis. Vitamin C is essential in replacing and strengthening connecting tissues of the body. As an antioxidant, it can reduce the effects of pollution, antibiotics, steroids, and oral contraceptives.

Vitamin D-3 (GPM)– A fat-soluble vitamin supports healthy bones and calcium and phosphorus absorption. It is involved in the regulation of the heartbeat and necessary for thyroid function and normal blood clotting. Can be received naturally by sunlight, 15 minutes per day, three (3) times per week.  In high-polluted areas, more vitamin D is needed.

Vitamin E (Mixed Tocopherols)- Fat soluble and specially suited to protect the oily portion of the body’s cells. The body needs a combination of oil and water-soluble antioxidants. Essential for health in the adrenal and pituitary glands. It improves circulation and is necessary for tissue healing and repair. Inhibits oxidation of lipids (fats) and the formation of free radicals. It protects other fat-soluble vitamins and retards aging. Mixed Tocopherols are considered the most potent form of all of the Vitamin E molecules.

Coral Calcium (35%)- Main constituent of teeth and bones. Helps regulate blood pressure, excitability of nerves and contractibility of muscles and heart. Helps control blood clotting and required for absorption of B-12. Aids in manufacture of acetylcholine, which helps transmit nerve impulses. Provides energy and structures protein of RNA and DNA.

Magnesium Yeast (20%)- This “anti-stress” mineral has a vast regulating effect on muscle contracting/relaxing and bone strengthening.  It is used in nerve function and low magnesium levels are believed to be associated with psychiatric problems. Deficiency plays a key role in all diseases, regulated by constriction of the heart and circulatory system; including heart attacks, strokes, migraine headaches, and kidney stone formation.

Iron Yeast 5%- This “anti-anemia” mineral aids in transporting oxygen to the cells and blood. It is responsible for the production of hemoglobin and myoglobin. Important in protein synthesis.

Biotin (Vitamin H) 0.5%-  Essential for the normal growth of all body tissues and cells, utilization of B complex vitamins, maintenance of skin, hair, all secreting glands, nerves, bone marrow, and male sex hormones.  It assists in the formation of enzymes.

Zinc Yeast 10%-     Zinc is a constituent of the antioxidant enzyme super oxide dismutase (SOD).

Necessary for the action of the B complex vitamins.  One of the main healing minerals for healthy hair and proper digestion of proteins, carbohydrates and essential for sugar conversion. A component of more than 60 enzymes including those essential to manufacturing the body’s natural antioxidants. Important for healthy skin and nails, effective wound healing, normal pregnancies, male virility, and sense of taste.

Manganese Yeast 10%-  Trace mineral, which helps the body to produce healthy connective tissue. Important in energy, protein, and fat metabolism. Essential for proper function of the nerves, the pituitary gland and other glands.

Selenium Yeast 0.2%- Strengthens the immune system by increasing antibody production in the body. It assists the body in utilizing oxygen and assists growth. Inhibits oxidation of lipids (fats). It works in tandem with Vitamin E very effectively. Prevents free radicals.

Chromium Polynicotinate (GPM) 0.2%- It is the most bio-available source of Chromium current on the market. Essential in converting fats into lean muscle mass. Helps to regulate the production of insulin

Protease-  Breaks down proteins.

Amylase-  Breaks down starches, carbohydrates, and some sugars.

Lipase–    Breaks down fats.